Serena Muratcıoğlu

Computational and experimental investigation of RAS homodimer and RAS-effector interactions

Ras proteins recruit and activate effectors, including Raf, that transmit receptor-initiated signals and regulates gene expression. Ras is believed to function as a monomer; however, since Raf dimerizes, it was suspected that Ras may also dimerize. Here we show that GTP-bound K-Ras4B forms stable homodimers using two interfaces.  We aim to confirm RAS dimerization in vivo and understand the effect of


Short Bio

Ph.D. Koç University-Chemical and Biological Engineering

B.Sc. Istanbul Technical University-Chemistry and Molecular Biology & Genetics