Emine Sıla Özdemir

Unraveling the Molecular Mechanism of Cdc42 and Rac1 Interactions with IQGAP2

IQGAP2 is a scaffold protein which plays central roles in cell-cell adhesion, polarity and cell motility. Rho GTPases Cdc42 and Rac1, in their GTP-bound active forms, interact with all three human IQGAP isoforms. IQGAP-Cdc42 interaction promotes metastasis by enhancing actin polymerization. However, despite their high degree of sequence identity, Cdc42 and Ra1 intrections with IQGAP show differences. We aim to reveal the interaction mechanisms of these proteins.

Unraveling the molecular mechanism of interactions of the Rho GTPases Cdc42 and Rac1 with the scaffolding protein IQGAP2. Ozdemir ES, Jang H, Gursoy A, Keskin O, Li Z, Sacks DB, Nussinov R (2018) . The Journal of Biological Chemistry. doi:10.1074/jbc.RA117.001596


Relation between Protein Intrinsic Normal Mode Weights and Pre-Existing Conformer Populations. Ozgur B*Ozdemir ES*, Gursoy A, Keskin O (2017) Journal of Physical Chemistry B 121 (15):3686-3700.doi:10.1021/acs.jpcb.6b10401 *These authors contributed equally to the work.

Red emitting, cucurbituril-capped, pH-responsive conjugated oligomer-based nanoparticles for drug delivery and cellular imaging. Pennakalathil J, Jahja E, Ozdemir ES, Konu O, Tuncel D (2014) Biomacromolecules 15 (9):3366-3374. doi:10.1021/bm500839j

Short Bio
B.Sc. Bilkent University-Molecular Biology and Genetics

M.Sc. Bilkent University-Molecular Biology and Genetics

Ph.D. Koç University-Chemical and Biological Engineering

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