Ras  protein is shown to interact with the proteins involved in crucial pathways such as MAPK and PI3K. Our group recently showed that specific mutations on Ras protein interfere with the p-ERK level within the cell. Using molecular dynamics simulation methods and computational analysis, we aim to have a deeper understanding how these mutations affects the interaction .Therefore, I am simulating the interactions of KRAS protein and Ras-Binding-Domain (RBD) of c-Raf protein.

B.Sc. İstanbul Technical University-Molecular Biology and Genetics