The common practice in structural PPI networks is to consider just one specific conformation for each protein. Yet it is not a comprehensive representation as it neglects the conformational changes of proteins which may lead to different protein interactions, functions, and downstream signaling. We propose a new representation for structural PPI networks which inspects the different conformations of proteins.

Publications
Enriching Traditional Protein-protein Interaction Networks with Alternative Conformations of Proteins. Halakou F, Kilic ES, Cukuroglu E, Keskin O, Gursoy A.  Sci Rep. 2017 Aug 3;7(1):7180.

Topological, functional, and structural analyses of protein-protein interaction networks of breast cancer lung and brain metastases, Halakou F, Gursoy A., Kilic E. S. and Keskin O. 2017 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB), Manchester, 2017, pp. 1-7.
doi: 10.1109/CIBCB.2017.8058539 ​

M.Sc. Kerman Graduate University of Technology-Information Technology Engineering